Title : CRP-albumin-lymphocyte index: Predicting in-hospital mortality after transcatheter closure of post-myocardial infarction ventricular septal rupture

Background: The C-reactive protein–albumin–lymphocyte (CALLY) index reflects inflammatory, immune, and nutritional status. This study evaluated its value in predicting in-hospital mortality in patients with post-myocardial infarction ventricular septal rupture (PIVSR) undergoing transcatheter closure.

Methods: We retrospectively analyzed 142 patients with PIVSR who underwent transcatheter closure between January 2018 and April 2025. Patients were divided into survivors (n=103) and non-survivors (n=39). Univariate and multivariate logistic regression analyses were used to identify predictors of in-hospital mortality, and receiver operating characteristic analysis assessed the predictive performance of CALLY.

Results: Among 142 patients, 81 (57%) were female, with a mean age of 66±8.18 years. CALLY values were lower in non-survivors. CALLY was associated with lower in-hospital mortality in univariate analysis (OR 0.213, 95% CI 0.050–0.544; P=0.012) and remained an independent predictor in multivariate analysis (OR 0.555, 95% CI 0.183–0.923; P=0.019). The AUC was 0.701 (95% CI 0.612–0.790; P<0.001), with 71.8% sensitivity and 63.1% specificity.

Conclusion: The CALLY index may be useful for predicting in-hospital mortality after transcatheter closure in patients with PIVSR.

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