Brugada Syndrome
Brugada syndrome is an inherited arrhythmia disorder associated with characteristic ECG patterns and an elevated risk of sudden cardiac death in structurally normal hearts. The Brugada Syndrome session provides a focused overview of genetics, pathophysiology, and clinical management of this challenging condition. Participants will review sodium channel abnormalities, precipitating factors, and dynamic ECG changes that make diagnosis complex. The session emphasizes how to distinguish true Brugada patterns from phenocopies caused by ischemia, electrolyte disturbances, or medications, ensuring that high-risk patients are recognized while avoiding overdiagnosis.
Clinicians and electrophysiology teams often look for a cardiology conference to clarify risk stratification and treatment decisions. This session examines clinical presentations—syncope, nocturnal agonal respirations, or incidental ECG findings—and how they relate to future event risk. Attendees will explore the role of provocative drug testing, family screening, and genetic counseling in comprehensive care. Detailed ECG analysis, including type 1, 2, and 3 patterns and the impact of lead placement, will help participants recognize Brugada syndrome confidently in routine practice.
A core theme is the long-term Brugada syndrome management strategy, especially when deciding which patients benefit most from implantable cardioverter defibrillators (ICDs). The session reviews current evidence on ICD implantation in symptomatic and high-risk asymptomatic individuals, as well as emerging options such as quinidine therapy, catheter ablation of arrhythmogenic substrates, and lifestyle modifications including fever control and avoidance of triggering drugs. Attendees will learn how to counsel patients regarding exercise, travel, and everyday risk mitigation while maintaining quality of life.
The session also addresses psychosocial and family implications of a genetic arrhythmia diagnosis. Participants will discuss multidisciplinary models that involve electrophysiologists, geneticists, psychologists, and specialized nurses to support patients and relatives navigating screening and treatment decisions. By the end, clinicians will have a structured framework for diagnosing Brugada syndrome, stratifying risk, initiating appropriate therapy, and organizing family-based care.
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Genetics and Pathophysiology
- Understanding sodium channel mutations and other genetic contributors to arrhythmic risk.
- Recognizing how fever, drugs, and autonomic tone unmask or accentuate ECG changes.
ECG Patterns and Provocative Testing
- Distinguishing type 1 Brugada pattern from other ST-segment elevations.
- Using sodium channel blocker challenge safely when indicated to confirm diagnosis.
Risk Stratification and Symptom Assessment
- Evaluating syncope history, nocturnal symptoms, and family sudden death.
- Integrating clinical and ECG markers into a comprehensive risk profile.
Family Screening and Counseling
- Identifying at-risk relatives through ECG and selective genetic testing.
- Providing clear information about inheritance, prognosis, and lifestyle guidance.
Management Strategies and Outcomes
Appropriate ICD Utilization
Selecting patients who derive the greatest survival benefit from device therapy.
Pharmacologic and Ablation Options
Considering quinidine or substrate ablation in high-risk or recurrent arrhythmia cases.
Lifestyle and Trigger Avoidance
Advising on fever management and drugs that may provoke arrhythmias.
Psychological Support and Education
Helping patients cope with anxiety related to sudden death risk and ICD shocks.
Coordinated Multidisciplinary Care
Aligning cardiology, genetics, and primary care around shared plans.
Continuous Knowledge Updating
Following evolving evidence on risk markers and novel treatments.
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