Therapeutic strategies for cardiovascular disease span pharmacology, device therapy, lifestyle interventions and procedural innovations; the Cardiovascular Diseases Treatment and Therapeutic Approaches session explores evidence-based treatments and emerging modalities that improve survival and quality of life. Sessions will review guideline-directed medical therapies for ischemic disease, heart failure and arrhythmias, and evaluate real-world application, adherence strategies and de-escalation where appropriate. Special emphasis is placed on precision therapeutics—matching drug classes, biologics and devices to mechanistic subtypes—and on multidisciplinary care models that integrate rehabilitation, nutrition and psychosocial support. Interventional and device-based approaches, such as transcatheter valves, left ventricular assist devices and advanced pacing therapies, will be considered alongside pharmacologic advances including novel lipid-lowering agents, anti-inflammatory strategies and RNA therapeutics. Practical panels will cover patient selection, peri-procedural management and long-term follow-up, while tutorials will provide stepwise approaches for implementing new therapies into routine practice. The session ties these themes back to the Therapeutics Conference program and discusses how to design registries and pragmatic trials that evaluate effectiveness, safety and cost-value in diverse healthcare settings.