Understanding the root causes of cardiovascular disease enables impactful prevention; the Causes, Prevention and Lifestyle Modifications session centers on etiologic drivers, risk reduction strategies and pragmatic lifestyle interventions that reduce population burden. This session synthesizes epidemiology, behavioral science and clinical prevention to present evidence-based programs that target smoking cessation, nutrition, physical activity, alcohol use and psychosocial risk. Presenters will highlight upstream determinants—social, environmental and metabolic factors—that potentiate cardiovascular risk, and demonstrate how tailored interventions address disparities across communities. Practical modules will review implementation of community screening, digital health-enabled coaching, structured cardiac rehabilitation and workplace wellness programs that measurably lower risk factors such as hypertension, dyslipidemia and obesity. The program features examples of scalable public-health interventions, policy levers for salt reduction and tobacco control, and clinical models that embed preventive care into primary and specialty settings. Case studies will illustrate successful population partnerships, insurer-led initiatives and employer-based interventions that achieved sustained risk reduction. Join colleagues to develop integrated prevention roadmaps and to evaluate metrics that demonstrate return on investment for prevention programs, connecting clinical practice with public health priorities at the core of the Cardiology Diseases Prevention Conference agenda.