High-quality diagnosis underpins effective cardiac care: the Detection, Diagnosis, and Imaging session spotlights advanced imaging modalities, biomarker-driven strategies and integrated diagnostic pathways that identify disease earlier and more accurately. Content spans echocardiography, cardiac MRI, CT coronary angiography, nuclear cardiology and point-of-care ultrasound, as well as molecular imaging and hybrid modalities that reveal pathophysiology at tissue and cellular scales. Presentations will examine the clinical utility and cost-effectiveness of imaging in risk stratification, management planning and procedural guidance. Sessions address best-practice protocols, quality assurance, AI-assisted image interpretation and strategies to harmonize multi-modality reports across centers. Attendees will learn how to integrate cardiac imaging with circulating biomarkers, genomics and clinical phenotyping to create robust diagnostic algorithms. Case-based workshops will focus on imaging selection for common dilemmas—ischemic evaluation, cardiomyopathy phenotyping, and structural disease assessment—and include hands-on demonstrations of acquisition and interpretation standards. The program aligns diagnostic advances with the broader Diagnostics & Imaging Conference theme to help clinicians, imagers and trialists implement reproducible, high-value diagnostic pathways.