To evaluate the role of I/D polymorphism of the angiotensin-converting enzyme (ACE) gene in patients

Aims:

To study the ID polymorphism of the angiotensin-converting enzyme (ACE) gene in patients with chronic heart failure (CHF) of Uzbek nationality.

Methods and Results:

Genotyping of the ACE gene ID polymorphism was carried out in 114 patients with CHF and 51 healthy donors of Uzbek nationality. Comparison of the frequencies of alleles and genotypes of the studied gene among patients with CHF and the comparison group was carried out using the case-control method. When the frequencies of the alleles of the ID polymorphism of the ACE gene were analyzed, it was found that the incidence of the D allele was significantly higher in the group of patients with CHF (51.4 versus 40.25% in the control group), while the frequency of the functionally significant allele I was 48.6% in the CHF group, lower than in the control group (59.8%). However, statistical processing did not show any significant differences (χ2 = 0.5; P = 0.4; OR = 0.8; 95% CI 0.4828, 1.399). The frequency of the I/I genotype decreases in the group of patients with CHF (31%) compared to the control group (47.1%). According to the odds ratio, the risk of developing CHF in the presence of the I/I genotype is insignificant. The decrease in the frequency of the I/D genotype of the ACE gene among patients (35.2%) compared to the control group (25.5%) turned out to be close to significant differences, which means that the heterozygous genotype can be considered as a protective factor for the development of the disease (χ2 = 1.3; p = 0.6, OR = 1.6; 95% CI 0.7166, 3.522). It is interesting to note that in the group of patients we identified a tendency toward an increase in the number of carriers of the homozygous D/D genotype. The frequency of this functionally unfavorable genotype was 33.8%. These data further strengthen the position of the D/D genotype of the ACE gene as a marker associated with the formation of CHF.

Conclusions:

Thus, the results of the study of the ACE gene locus under study revealed the role of the D/D genotype as an independent marker of CHF development.

Tagaeva Dilnoza is a cardiac rehabilitation specialist specializing in the study of cardiac diseases and rehabilitation treatment methods. She has participated in 4 Republican projects in this area and published numerous papers on cardiac diseases. She is currently the acting head of the Rehabilitation Laboratory at the Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation Tashkent.