Title: Diabetic cardiomyopathy and metal-mediated inflammation and cell deaths

Cardiac inflammation and myocyte death are essential for initiating the pathogenesis and progression of various etiological cardiomyopathies, including diabetic cardiomyopathy (DCM), reported in 1972. Cardiac cell death was detected in the hearts of patients with diabetes and ani [....] » Read More

Title: High rates of mineralocorticoid receptor antagonist discontinuation in patients with hypertension: Insights from the enlighten study

Objective: Mineralocorticoid receptor antagonists (MRAs) are indicated for several cardiovascular (CV) conditions, including heart failure (HF) and hypertension (HTN). However, adverse drug reactions or dose-limiting side-effects may lead to discontinuation. We aimed to descri [....] » Read More

Title: Principles and standards for designing and managing integration and interoperability of intelligent and ethical transformed health ecosystems

Health and social care systems around the world undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), considering the individual health status, conditions, genetic and genomic dispositions in personal, social, occupational, [....] » Read More

Title: Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and KATP channel function in the atrium from patients with atrial fibrillation

Background: Atrial fibrillation (AF) is the most common form of arrhythmia and is a growing clinical problem. Post-translational modifications (PTMs) constitute crucial epigenetic mechanisms but modification of lysine 2-hydroxyisobutyrylation (Khib) in AF is still unknown. This s [....] » Read More

Title: Unveiling the role of extracellular nucleic acids in hypoxia-induced myocardial injury

Cardiovascular diseases (CVDs), particularly myocardial infarction (MI), have been linked to hypoxia-induced cellular stress, independent of infectious factors. Hypoxia triggers the release of endogenous ligands from necrotic cells, including circulating nucleic acids (CNAs) like [....] » Read More

Title: Multifunctional nanosystems for precision diagnosis and detoxification in cardiovascular diseases: From multimodal imaging of myocarditis to cardioprotective chemotherapy

Background and Objective: Early diagnosis and cardioprotection remain key challenges in the management of inflammatory and chemotherapy-induced cardiac injuries. To address these, our research team has developed macrophage membrane-modified nanoparticles (MM/NPs) to guide early n [....] » Read More

Title: DICAR-JP regulates ribosome migration, a new theory of mitochondrial protein production

DICAR, a circular RNA, is known to play a cardioprotective role in diabetic cardiomyopathy (DCM). DICAR-JP is a short fragment of DICAR that represents its active functional domain. We showed that DICAR and DICAR-JP interact with nascent polypeptide–associated complex alpha [....] » Read More

Title: Ginseng polysaccharides reduce myocardial ischemia-reperfusion injury via suppressing ferroptosis

Background and Purpose: Myocardial ischemia-reperfusion injury (MIRI) is a major contributor to global morbidity and mortality, necessitating novel therapeutic strategies. WGPA, polysaccharides fraction derived from Panax ginseng C.A. Meyer, exhibits diverse pharmacological prope [....] » Read More

Title: Advancing the care of heart failure and T2DM

Heart failure is a clinical syndrome caused by a structural and/or functional cardiac abnormality, resulting in a reduced cardiac output and/or elevated intracardiac pressures at rest or during stress.1   Heart failure poses a significant global disease burden, more th [....] » Read More

Title: Study of the relationship between the Triglyceride-Glucose (TG/G) index and the species ratio of the microbiome

The triglyceride-glucose (TG/G) index is widely recognized as a surrogate marker of insulin resistance, providing valuable insights into the risk of cardiovascular diseases (CVD). Its elevation is associated with vascular calcification, coronary and carotid artery stenosis, and a [....] » Read More

Title: Prognostic impact of right bundle branch block in acute anterior wall STEMI: A cross-sectional study

Background: Right bundle branch block (RBBB) in acute anterior wall ST-segment elevation myocardial infarction (AW-STEMI) may indicate extensive myocardial injury, yet its independent prognostic value remains uncertain.   Methods: We conducted a cross-sectional observa [....] » Read More

Title: Laser catheter ablation of long-lasting chronic persistent atrial fibrillation (AF)

Graphical abstract: High Density (HD) lasermapping guided AF ablation: gradual abatement of local atrial potential amplitudes (AA1) with abolishment in 4s. This 7th laser impact aimed at the posterior left atrial wall achieved recurrence to sinus rhythm (SR) A2A3 in the 8th se [....] » Read More

Title: Soliton waves perform a fundamental function in the heart

The biochemical model, which has existed for over 100 years, is insufficient to explain the phenomenon of life. Translating everything into the criteria of classical chemistry or electrochemistry gives the impression of regression. Beyond traditional, well-known chemical reaction [....] » Read More

Title: AI- atria oracle - an artificial intelligence sentinel for precision prognostication of atrial fibrillation risks in post-cardiac surgery care- pilot study

Introduction: Embarking on the forefront of cardiac care, this study pioneers an AI-driven scoring system for predicting atrial fibrillation risks post cardiac surgery. Drawing insights from established methodologies, ChatGPT crafts a sophisticated tool, demonstrating robust p [....] » Read More

Title: Yasser’s electrocardiographic palpitations wave with bilobed apical floating heart syndrome in yasser’s fibrillation-A strange innovative cardiovascular and radiological discoveries-A case report

Atrial fibrillation (AF) is the most common arrhythmia. It is known leading cause of ischemic cerebrovascular accidents. Yasser’s fibrillation (sinusoidal AF) or mixed AF is a new cardiovascular discovery. The partial sino-atrial nodal function has an essential role in the [....] » Read More

Title: Danon disease (clinical case)

Background: In 1981 Morris Danon described 2 patients with severe hypertrophic cardiomyopathy as a glycogen storage disease of the heart.  Danon disease is a rare X-linked dominant genetic disorder that manifests with the clinical triad of cardiomyopathy, skeletal myopathy, [....] » Read More

Title: Clinical efficacy and mechanistic study of fulvning granules in symptomatic atrial fibrillation: A randomized controlled trial with untargeted metabolomics analysis

Background: Atrial fibrillation (AF) is the most common sustained arrhythmia and a major contributor to global morbidity and mortality. Although antiarrhythmic drugs and catheter ablation have advanced AF management, their effectiveness remains limited. Fulvning Granules (FLN), a [....] » Read More

Title: Identification of mitochondria-associated endoplasmic reticulum membranes-related biomarkers for atrial fibrillation

Aims: To provide novel insights into the diagnosis of atrial fibrillation (AF), we aimed to identify mitochondria-associated endoplasmic reticulum membranes (MAMs)-related biomarkers for AF.   Methods: A comprehensive analysis was conducted to identify MAM-related biom [....] » Read More

Title: Hybrid RFR-FFR decision-making strategy for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome

Objective: To developed a hybrid resting full-cycle ratio (RFR)- fractional flow reserve (FFR) decision-making approach for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).   Materials and methods: This [....] » Read More

Title: To evaluate the role of I/D polymorphism of the angiotensin-converting enzyme (ACE) gene in patients

Aims: To study the ID polymorphism of the angiotensin-converting enzyme (ACE) gene in patients with chronic heart failure (CHF) of Uzbek nationality.   Methods and Results: Genotyping of the ACE gene ID polymorphism was carried out in 114 patients with CHF and 51 [....] » Read More