CVS 2026

Title: Diabetic cardiomyopathy and metal-mediated inflammation and cell deaths

Cardiac inflammation and myocyte death are essential for initiating the pathogenesis and progression of various etiological cardiomyopathies, including diabetic cardiomyopathy (DCM), reported in 1972. Cardiac cell death was detected in the hearts of patients with diabetes and ani [....] » Read More

Title: High rates of mineralocorticoid receptor antagonist discontinuation in patients with hypertension: Insights from the enlighten study

Objective: Mineralocorticoid receptor antagonists (MRAs) are indicated for several cardiovascular (CV) conditions, including heart failure (HF) and hypertension (HTN). However, adverse drug reactions or dose-limiting side-effects may lead to discontinuation. We aimed to descri [....] » Read More

Title: Principles and standards for designing and managing integration and interoperability of intelligent and ethical transformed health ecosystems

Health and social care systems around the world undergo a transformation towards personalized, preventive, predictive, participative precision medicine (5PM), considering the individual health status, conditions, genetic and genomic dispositions in personal, social, occupational, [....] » Read More

Title: Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and KATP channel function in the atrium from patients with atrial fibrillation

Background: Atrial fibrillation (AF) is the most common form of arrhythmia and is a growing clinical problem. Post-translational modifications (PTMs) constitute crucial epigenetic mechanisms but modification of lysine 2-hydroxyisobutyrylation (Khib) in AF is still unknown. This s [....] » Read More

Title: Unveiling the role of extracellular nucleic acids in hypoxia-induced myocardial injury

Cardiovascular diseases (CVDs), particularly myocardial infarction (MI), have been linked to hypoxia-induced cellular stress, independent of infectious factors. Hypoxia triggers the release of endogenous ligands from necrotic cells, including circulating nucleic acids (CNAs) like [....] » Read More

Title: Safeguarding accuracy in ABG testing: Managing preanalytical errors and meeting POCT standards under ISO 15189:2022

Background In patients with cardiac failure, arterial blood gas (ABG) testing provides critical insights into oxygenation, acid–base balance, and tissue perfusion. These results often guide immediate therapeutic interventions such as oxygen therapy, ventilation strategie [....] » Read More

Title: Therapeutic targeting of mitochondrial dysfunction in heart failure: A grade-assessed systematic review & meta-analysis of clinical outcomes

Introduction: Mitochondrial dysfunction is increasingly recognized as a central contributor to heart failure (HF) pathophysiology, driving oxidative stress, apoptosis, and energy loss in cardiomyocytes. While therapeutic agents targeting to restore mitochondrial function like [....] » Read More

Title: Coronary CT Angiography (CCTA) and the role of structured reporting in contemporary CAD management

Introduction: Coronary Computed Tomography Angiography (CCTA) is a noninvasive, cost-effective, and rapid heart imaging test essential for the early and accurate detection, diagnosis, and risk stratification of Coronary Artery Disease (CAD). CCTA uses an intravenous injection of [....] » Read More

Title: Advancement in management of hypertension: Renal denervation therapy

Overview This presentation explores the evolution, mechanism, clinical evidence, and patient selection for renal denervation (RDN) as a therapy for hypertension, especially resistant cases. 1. Background and Need Resistant Hypertension is highlighted as a major clinic [....] » Read More

Title: Multifunctional nanosystems for precision diagnosis and detoxification in cardiovascular diseases: From multimodal imaging of myocarditis to cardioprotective chemotherapy

Background and Objective: Early diagnosis and cardioprotection remain key challenges in the management of inflammatory and chemotherapy-induced cardiac injuries. To address these, our research team has developed macrophage membrane-modified nanoparticles (MM/NPs) to guide early n [....] » Read More

Title: DICAR-JP regulates ribosome migration, a new theory of mitochondrial protein production

DICAR, a circular RNA, is known to play a cardioprotective role in diabetic cardiomyopathy (DCM). DICAR-JP is a short fragment of DICAR that represents its active functional domain. We showed that DICAR and DICAR-JP interact with nascent polypeptide–associated complex alpha [....] » Read More

Title: Ginseng polysaccharides reduce myocardial ischemia-reperfusion injury via suppressing ferroptosis

Background and Purpose: Myocardial ischemia-reperfusion injury (MIRI) is a major contributor to global morbidity and mortality, necessitating novel therapeutic strategies. WGPA, polysaccharides fraction derived from Panax ginseng C.A. Meyer, exhibits diverse pharmacological prope [....] » Read More

Title: Upregulation of GABRB1 drives N-linked glycosylation of CDH2 to potentiate dilated cardiomyopathy

Background ? The brain – heart axis, a dynamic network integrating neural, mechanical, and biochemical pathways, is essential for cardiovascular homeostasis. Autonomic dysregulation is implicated in dilated cardiomyopathy (DCM), yet the molecular mechanisms linking neuromod [....] » Read More

Title: Unleashing SPC power: the first data on efficacy, safety and adherence of bisoprolol amlodipine SPC in China

Background Single-pill combination (SPC) of bisoprolol and amlodipine has shown promising results in blood pressure (BP) and heart rate (HR) control. However, clinical studies of this combination in Chinese patients remain limited.   Methods This was a 12-week, interve [....] » Read More

Title: Association between healthy lifestyle and ischemic stroke risk in elderly rural hypertensive patients

Background: Assessing risk factors associated with ischemic stroke risk is important for planning public health interventions, but whether this risk can be changed by modifiable lifestyle factors is unknown. We aimed to explore whether healthy lifestyles (never smoking, never dri [....] » Read More

Title: Association between reproductive history, healthy lifestyle and cardiovascular disease in rural women with hypertension

Objective: To explore the relationship between reproductive factors, healthy lifestyles, and the risk of cardiovascular disease (CVD) among rural women aged 65 years and older with hypertension, and to provide key evidence for primary prevention practices for CVD in this populati [....] » Read More

Title: Cardiovascular health and carotid atherosclerosis among county residents in henan province: evidence from the le8 scoring system

Objective: To estimate the prevalence of carotid atherosclerosis (CAS) among county residents in Henan Province and to evaluate cardiovascular health (CVH) using the American Heart Association’s Life’s Essential 8 (LE8) score. We assessed associations between CVH and [....] » Read More

Title: Predictive value of obesity indices for carotid atherosclerosis: An interpretable machine learning study

Objective: To investigate the associations between commonly used obesity indices and the risk of carotid atherosclerosis (CAS), and to provide evidence for the early identification of individuals at high risk.   Methods:  A cross-sectional survey was conducted bet [....] » Read More

Title: Very early cardiac hemodynamic changes after atrial fibrillation ablation

Background: All chambers’ systolic functions were improved with long-term follow-up after catheter ablation (CA). However, changes on cardiac function on very early phase (within 48 hours) has not been thoroughly investigated.   Objectives: This study aimed to ev [....] » Read More

Title: Mesenchymal stem cells in treating myocardial infarction

Mesenchymal stem cells (MSCs) have emerged as a highly promising strategy in regenerative medicine due to their self-renewal, pluripotency and immunomodulatory properties. MSCs are nonhematopoietic, multipotent stem cells that can differentiate into various mesodermal lineages an [....] » Read More

Title: Advancing the care of heart failure and T2DM

Heart failure is a clinical syndrome caused by a structural and/or functional cardiac abnormality, resulting in a reduced cardiac output and/or elevated intracardiac pressures at rest or during stress.1   Heart failure poses a significant global disease burden, more th [....] » Read More

Title: Low dose vs. higher doses of colchicine for secondary prevention of ischemic stroke and cardiovascular disease. an updated grouped meta-analysis of landmark trials

Introduction: The role of colchicine in secondary cardiovascular prevention remains unclear and debatable when it comes to optimal dosing strategies and patient selection. We conducted a systematic review and meta-analysis comparing low-dose versus higher-dose colchicine for seco [....] » Read More

Title: Study of the relationship between the Triglyceride-Glucose (TG/G) index and the species ratio of the microbiome

The triglyceride-glucose (TG/G) index is widely recognized as a surrogate marker of insulin resistance, providing valuable insights into the risk of cardiovascular diseases (CVD). Its elevation is associated with vascular calcification, coronary and carotid artery stenosis, and a [....] » Read More

Title: Socioeconomic, parental, and nutritional factors associated with congenital heart disease in children: Insights from a hospital-based case-control study in Kabul, Afghanistan

Background: Congenital heart disease (CHD) is one of the most common congenital anomalies and a leading cause of childhood morbidity and mortality worldwide. The etiology of CHD is multifactorial, involving genetic predisposition, environmental influences, maternal health, and so [....] » Read More

Title: Comparison of endovascular aspiration thrombectomy vs. rheolytic thrombectomy for occluded reno-visceral arteries: a single center experience

Background: The aim of this study was to compare the effectiveness and the safety of endovascular therapy with rheolytic thrombectomy using the AngioJet™ vs. aspiration thrombectomy using the Penumbra CAT™ for treatment of the visceral ischemia caused by occluding l [....] » Read More

Title: Laser catheter ablation of long-lasting chronic persistent atrial fibrillation (AF)

Graphical abstract: High Density (HD) lasermapping guided AF ablation: gradual abatement of local atrial potential amplitudes (AA1) with abolishment in 4s. This 7th laser impact aimed at the posterior left atrial wall achieved recurrence to sinus rhythm (SR) A2A3 in the 8th se [....] » Read More

Title: Our research comparing traditional and pritikin intensive cardiac rehabilitation outcomes

Purpose: The objective of this study was to assess differences in dietary behavior and clinical risk factor outcomes and explore predictors of change among patients participating in traditional and Pritikin intensive cardiac rehabilitation (CR).   Methods:  This s [....] » Read More

Title: Soliton waves perform a fundamental function in the heart

The biochemical model, which has existed for over 100 years, is insufficient to explain the phenomenon of life. Translating everything into the criteria of classical chemistry or electrochemistry gives the impression of regression. Beyond traditional, well-known chemical reaction [....] » Read More

Title: Cardiogenic shock: Latest status of all mechanical support devices

Background: Despite developments in revascularization, the mortality rate via cardiogenic shock (CS) caused by acute myocardial infarction (AMI) is still high. With the goal to preserve end-organ function, unload the left ventricle, and boost systemic perfusion, mechanical cir [....] » Read More

Title: AI- atria oracle - an artificial intelligence sentinel for precision prognostication of atrial fibrillation risks in post-cardiac surgery care- pilot study

Introduction: Embarking on the forefront of cardiac care, this study pioneers an AI-driven scoring system for predicting atrial fibrillation risks post cardiac surgery. Drawing insights from established methodologies, ChatGPT crafts a sophisticated tool, demonstrating robust p [....] » Read More

Title: The effect of monoclonal antibodies targeting IL-6 in inflammatory status in cardiovascular diseases: a systematic review and meta-analysis

Introduction: Recent clinical trials have firmly established that inflammation plays a causal role in human atherosclerosis, the primary driver of cardiovascular diseases (CVDs). Targeting inflammatory pathways, such as interleukin-6 (IL-6), may offer a novel strategy to reduce c [....] » Read More

Title: Yasser’s electrocardiographic palpitations wave with bilobed apical floating heart syndrome in yasser’s fibrillation-A strange innovative cardiovascular and radiological discoveries-A case report

Atrial fibrillation (AF) is the most common arrhythmia. It is known leading cause of ischemic cerebrovascular accidents. Yasser’s fibrillation (sinusoidal AF) or mixed AF is a new cardiovascular discovery. The partial sino-atrial nodal function has an essential role in the [....] » Read More

Title: Innovations in cardiac nursing: Evidence-based strategies for optimizing patient outcomes in acute and critical care

Background: Innovations in cardiac nursing, including evidence-based interventions and advanced patient management strategies, are essential to improve outcomes in acute and critical care settings. Despite growing interest, limited research has examined the combined impact of sta [....] » Read More

Title: Danon disease (clinical case)

Background: In 1981 Morris Danon described 2 patients with severe hypertrophic cardiomyopathy as a glycogen storage disease of the heart.  Danon disease is a rare X-linked dominant genetic disorder that manifests with the clinical triad of cardiomyopathy, skeletal myopathy, [....] » Read More

Title: Single cell analysis of endothelial cells in male and female developing heart

Background: Sex differences exist in the circulatory system and the onset of cardiovascular diseases. While these differences are primarily attributed to sex hormones, it remains unclear when sex differences emerge in the cardiovascular system and when they begin to cause func [....] » Read More

Title: Blood pressure management after mechanical thrombectomy is as crucial as reperfusion status in acute large vessel occlusion

Background: Blood pressure variability (BPV) is known to influence outcomes after mechanical thrombectomy (MT) in acute large vessel occlusion (LVO), and its impact may vary depending on the degree of collateral flow prior to MT. This study aimed to investigate whether BPV after [....] » Read More

Title: An evaluation of the development of nursing service systems in assisting patients with the use of cardiac event recorder for outpatients at a university hospital

Background: Patients with suspected cardiac arrhythmias frequently present to healthcare facilities after symptomatic episodes have resolved, making timely diagnosis challenging. Portable cardiac event recorders enable capturing abnormal heart rhythms during symptomatic episode [....] » Read More

Title: The incidence of cardiac arrhythmia using telemetry, portable ECG monitors, in inpatients at faculty of medicine tertiary care hospital

Background: Cardiac arrhythmias represent a significant clinical complication among hospitalized patients, particularly in those with underlying cardiovascular disease. Continuous telemetry monitoring provides real-time electrocardiographic surveillance, enabling prompt detection [....] » Read More

Title: Clinical efficacy and mechanistic study of fulvning granules in symptomatic atrial fibrillation: A randomized controlled trial with untargeted metabolomics analysis

Background: Atrial fibrillation (AF) is the most common sustained arrhythmia and a major contributor to global morbidity and mortality. Although antiarrhythmic drugs and catheter ablation have advanced AF management, their effectiveness remains limited. Fulvning Granules (FLN), a [....] » Read More

Title: Identification of mitochondria-associated endoplasmic reticulum membranes-related biomarkers for atrial fibrillation

Aims: To provide novel insights into the diagnosis of atrial fibrillation (AF), we aimed to identify mitochondria-associated endoplasmic reticulum membranes (MAMs)-related biomarkers for AF.   Methods: A comprehensive analysis was conducted to identify MAM-related biom [....] » Read More

Title: Shock index as clinical independent predictor of in-hospital mortality in acute coronary syndrome patients: a 5-year retrospective study

Introduction/Objective: In the Philippines, acute coronary syndrome (ACS) is a leading cause of mortality. Risk assessment is crucial for estimating prognosis and indicating the need for a more aggressive approach. Shock index (SI), ratio of heart rate and systolic blood pressure [....] » Read More

Title: Comparison of MIRACLE2 and NULL-PLEASE scores for predicting survival and neurological outcomes following out-of-hospital cardiac arrest

Aims Early prognostication following out-of-hospital cardiac arrest (OOHCA) remains challenging. The MIRACLE2 and NULL-PLEASE scores have been developed to aid early outcome prediction; however, direct comparative data between the two are limited. This study aimed to evaluate [....] » Read More

Title: Hybrid RFR-FFR decision-making strategy for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome

Objective: To developed a hybrid resting full-cycle ratio (RFR)- fractional flow reserve (FFR) decision-making approach for physiology-guided coronary revascularization in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).   Materials and methods: This [....] » Read More

Title: To evaluate the role of I/D polymorphism of the angiotensin-converting enzyme (ACE) gene in patients

Aims: To study the ID polymorphism of the angiotensin-converting enzyme (ACE) gene in patients with chronic heart failure (CHF) of Uzbek nationality.   Methods and Results: Genotyping of the ACE gene ID polymorphism was carried out in 114 patients with CHF and 51 [....] » Read More