Managing cardiovascular disease in special populations—pregnant women, elderly patients, people with congenital heart disease, and those with multimorbidity—requires tailored approaches. The Cardiology in Special Populations session examines diagnostic challenges, therapy adaptations and care models that meet the needs of diverse groups. Topics include pregnancy-associated cardiovascular disease and management of congenital lesions across the lifespan, geriatric cardiology with frailty and polypharmacy considerations, and tailored strategies for immunocompromised or disabled patients. Sessions will present guidelines for modification of interventions, risk assessment frameworks, and case-based algorithms for complex scenarios, with attention to quality-of-life measures and shared decision-making. Workshops will explore medication safety, device selection, and coordination of multidisciplinary teams to optimize outcomes. Presenters will also discuss health equity, cultural competence and system-level pathways that improve access and continuity of care—connecting these priorities to the broader Special Populations Cardiology Conference agenda.