Gene Therapy in Cardiology
Gene Therapy in Cardiology represents a revolutionary frontier in cardiovascular medicine, aiming to correct genetic defects, modulate molecular pathways, and enhance cardiac repair. This session explores current scientific understanding, clinical trial progress, vector platforms, delivery challenges, and future therapeutic opportunities. With rising global interest, researchers increasingly search for a dedicated cardiology conference to understand this rapidly expanding field.
The description reviews the molecular basis of cardiovascular disease, focusing on inherited cardiomyopathies, arrhythmia syndromes, hypertension-related changes, vascular dysfunction, and heart failure. Participants will understand how genetic variants and molecular signaling drive disease progression, and how gene therapy aims to modify these pathways.
A major component is implementing advanced cardiology gene therapy strategies, exploring gene replacement, gene silencing (RNAi), genome editing (CRISPR/Cas9), AAV-based vectors, lipid nanoparticles, viral vs. non-viral delivery, and tissue-targeted distribution. The session covers cardiac-specific promoters, vector tropism, off-target risks, and immune responses that influence therapy success.
Case discussions explore applications in Duchenne cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic syndromes, lipid disorders, ischemic tissue repair, and congenital heart defects. Participants will review preclinical breakthroughs and early-phase clinical trial outcomes.
Future innovations include base editing, prime editing, programmable epigenetic modification, multi-vector systems, mRNA therapies, and precision delivery through catheter-based platforms. By the end of this session, attendees will appreciate how gene therapy is shaping the next generation of cardiovascular care.
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Genetic Foundations of Heart Disease
- Understanding pathogenic variants and molecular targets.
- Recognizing indications for gene-based interventions.
Vector Systems and Delivery Platforms
- Evaluating viral and non-viral options.
- Selecting delivery routes for optimal myocardial uptake.
Editing and Modulation Techniques
- Using CRISPR, RNAi, and replacement genes.
- Addressing off-target and immunologic concerns.
Clinical and Translational Advances
- Reviewing current clinical trial results.
- Identifying candidates for future gene therapies.
Benefits to Patients and Systems
Potential for Cure Instead of Management
Gene therapy targets root molecular causes.
Reduced Disease Progression
Modifying pathways slows or reverses deterioration.
Personalized Precision Care
Therapies tailored to genetic profiles enhance success.
Breakthrough Options for Rare Conditions
New pathways for previously untreatable disease.
Lower Long-Term Healthcare Burden
Durable therapies reduce chronic medication use.
Major Innovation Force
Advances accelerate drug, device, and biomarker development.
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