Understanding the physics of circulation is essential for precision management. The Hemodynamics and Cardiac Function session explores ventricular-vascular interactions, load-dependent physiology, pressure–volume relations and techniques to quantify cardiac performance in health and disease. Presentations will cover invasive and non-invasive haemodynamic assessment, simulation models, novel catheter technologies and imaging-based hemodynamic surrogates. Sessions include translational studies linking mechanical stress to remodeling, and clinical workshops on interpreting pressure–volume loops, advanced catheterization lab techniques and optimizing device settings for ventricular unloading. Attendees will examine how hemodynamic phenotyping informs therapy selection in heart failure, shock and valvular disease, and how computational models enhance patient-specific planning. The program integrates hemodynamic modeling with interventional strategies and the broader Hemodynamics Conference themes to guide precision interventions.