Platelet inhibition is central to the prevention of arterial thrombosis in coronary artery disease, acute coronary syndromes, and post–percutaneous coronary intervention. The Antiplatelet Therapy session provides an in-depth review of how to select, combine, and tailor antiplatelet drugs for diverse patient groups. Participants will explore mechanisms and evidence for aspirin, P2Y?? inhibitors, and newer agents, with a focus on dual and triple therapy strategies in real-world practice. The session emphasizes clinical reasoning: which regimen, at what dose, and for how long, in order to balance ischemic protection with bleeding risk.

As guidelines evolve, many clinicians search for an cardiology conference that explains how trial data translate into everyday decisions in the catheterization lab, ward, and clinic. This session covers antiplatelet use across the spectrum of stable coronary disease, NSTEMI, STEMI, and high-risk PCI. Attendees will learn how to choose between clopidogrel, prasugrel, and ticagrelor, when to consider de-escalation, and how to personalize therapy for older adults, those with prior bleeding, or patients requiring long-term oral anticoagulation. Special consideration is given to patients with complex stenting, left main disease, or multivessel interventions where ischemic risk is substantial.

The session also highlights dual antiplatelet therapy strategies and evolving concepts such as shortened DAPT duration, P2Y?? monotherapy, and tailored regimens guided by bleeding and ischemic scores. Participants will explore the implications of high on-treatment platelet reactivity, genetic testing, and drug interactions, as well as management of peri-operative antiplatelet interruption and reinitiation. Case-based discussions will walk through difficult scenarios like stent thrombosis, intracranial bleeding, or urgent surgery shortly after PCI, underscoring the need for structured, team-based decision-making.

Beyond drug selection, the session addresses practical issues like patient counseling, adherence, and coordination with primary care, neurology, and gastroenterology. Attendees will see how standardized order sets, checklists, and cross-specialty communication can reduce medication errors and improve continuity of care. By integrating evidence, guidelines, and nuanced clinical judgment, participants will leave better prepared to design antiplatelet plans that are safe, effective, and individualized.