Repairing injured myocardium is a frontier with transformative potential. The Cardiac Regeneration and Repair Mechanisms session explores cellular therapies, gene editing, tissue engineering and molecular strategies that promote myocardial repair, reverse fibrosis and restore function. Speakers will present preclinical advances in stem cell derivatives, exosome biology, gene-delivery vectors and CRISPR-based approaches, along with translational pathways to early-phase clinical trials. Discussions will emphasise mechanisms of cardiomyocyte proliferation, extracellular matrix remodelling, angiogenesis and immunomodulation that underpin regeneration. Panels will review safety, delivery methods, dosing strategies and standardized outcome measures for regenerative trials, including imaging and biomarker endpoints. Workshops focus on manufacturing, regulatory constraints and scalable production for cell-based products, as well as ethical considerations and patient selection frameworks. Attendees will gain a balanced view of promise and pitfalls, learning how mechanistic insights map to feasible clinical strategies—within the Cardiac Regeneration Conference scope—and will examine case examples of early regenerative interventions and their outcomes.