Donor Heart Preservation

Donor Heart Preservation is a critical component of cardiac transplantation, influencing graft viability, recipient survival, and long-term post-transplant outcomes. This session explores the physiological, logistical, and technological factors involved in maintaining myocardial integrity from procurement to implantation. As transplant specialists increasingly search for a focused cardiology conference, this session delivers a deep understanding of preservation strategies, organ transport systems, and metabolic optimization.

The description examines the fundamental challenges of ischemia–reperfusion injury, myocardial energy depletion, inflammation, endothelial dysfunction, and oxidative stress during heart transport. Participants will review traditional cold static storage using preservation solutions and explore advanced perfusion-based methods that maintain warm, oxygenated circulation.

A major emphasis is placed on implementing advanced donor heart preservation strategies, including ex vivo heart perfusion (EVHP), normothermic machine perfusion, hypothermic perfusion, optimized cardioplegia solutions, metabolic support agents, and strategies to extend permissible ischemia time. The content explains how these approaches improve donor organ evaluation, reduce discard rates, and enhance matching flexibility for transplant centers.

The session addresses donor selection, hemodynamic optimization before procurement, hormonal therapy, and strategies to manage extended-criteria donors. Participants will explore transport logistics, perfusion monitoring variables (flow, lactate, metabolic markers), and methods for assessing graft viability prior to transplantation.

The session concludes with major innovations: portable perfusion systems, biomarker-driven viability testing, gene-treated donor organs, xenotransplantation insights, and AI-assisted logistics planning. By the end, attendees will have expanded understanding of how modern preservation extends graft life and improves transplant success.

Core Concepts in Heart Preservation

Mechanisms of Myocardial Injury

  • Understanding ischemia–reperfusion pathways.
  • Recognizing metabolic and structural vulnerability.

Preservation Methods and Technologies

  • Comparing static cold storage and perfusion systems.
  • Selecting solutions and perfusates for optimal protection.

Donor Optimization and Assessment

  • Stabilizing hemodynamics before procurement.
  • Evaluating donor heart function and viability.

Transport and Implantation Planning

  • Coordinating teams for efficient transport.
  • Monitoring key physiological markers in transit.

Outcome and Patient Benefits

Enhanced Long-Term Survival
Protected myocardium promotes durability.

 

Innovation-Driven Improvements
Emerging systems elevate transplantation standards.

Extended Donor Heart Availability
Improved preservation increases usable grafts.

Better Post-Transplant Recovery
Optimized preservation minimizes reperfusion injury.

Reduced Organ Discard Rates
Perfusion systems rescue marginal or borderline hearts.

Greater Matching Flexibility
Extending preservation windows improves logistics.

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