The interplay between heritable DNA variation and reversible epigenetic programming shapes susceptibility, progression and therapeutic response in many heart and vascular diseases. The Genetics and Epigenetics in Cardiology session focuses on how genome sequencing, polygenic risk scores, methylation patterns and histone modifications provide mechanistic insight and enable precision approaches to diagnosis and treatment. Speakers will present human genetic discoveries, functional follow-up studies, and epigenomic mapping efforts that connect genetic loci to cellular phenotypes. The session explores clinical translation of genetic knowledge—how to apply cardiac genetics in risk stratification, cascade screening and variant interpretation—and how epigenetic biomarkers may serve as dynamic readouts of disease activity or treatment response. Panels will cover implementation challenges, including variant classification, consent and data-sharing frameworks, and equity in genetic testing access. Workshops will demonstrate analytical pipelines for variant calling, polygenic score construction and integrative multi-omic analysis. Attendees will also consider ethical, legal and social implications as well as clinical pathways to incorporate genomic and epigenomic data into multidisciplinary care models aligned with the broader Cardiology Genetics Conference program goals.