The study of Pathophysiology of Cardiovascular Diseases examines the biological and systemic mechanisms that lead to heart and vascular dysfunction, providing the mechanistic foundation clinicians and researchers need to develop targeted therapies. This session brings mechanistic science together with clinical insight to reveal how genetics, inflammation, metabolic dysfunction and environmental exposures drive conditions such as atherosclerosis and myocardial injury, and why individuals differ in disease progression and response to treatment. Attendees will explore cellular signaling cascades, maladaptive remodeling, microvascular dysfunction and immune–cardiac interactions, and discuss how advanced models—from organoids to large-animal systems—help predict therapeutic efficacy. Speakers will present integrative frameworks that connect molecular phenotypes with hemodynamic stressors, offering new biomarkers and mechanistic endpoints for clinical trials. Practical sessions will address study design, reproducibility, and translational checkpoints to move mechanistic discoveries into interventional studies. Join colleagues to deepen your understanding of disease causation and heterogeneity and to identify high-value therapeutic targets that can be tested in future trial programs and implementation studies. The program also emphasizes systems-level concepts in the Pathophysiology Conference context, connecting bench research with clinical decision-making and population risk stratification.